HealthRx starts at $99/mo (all-in, includes medication); DirectMeds at $179/mo (all-in, includes medication). Both prescribe GLP-1 medication — HealthRx offers compounded semaglutide & tirzepatide, DirectMeds compounded semaglutide & tirzepatide. Here's how they compare on price, medications, support and transparency.
Bottom line: HealthRx wins
It's a near-tie at 8.0/10 — HealthRx takes it on the lower starting price. DirectMeds is a close alternative if you want the broadest medication menu and the flexibility to switch or adjust dose.
Round by round
We scored both programs on the four factors in our methodology — value, support, medications and transparency. HealthRx takes 2, DirectMeds takes 2. Here's how each shook out.
Value
What you get for the price — not just the lowest sticker. A premium program that includes FDA-approved medication, insurance help and real support can be good value. HealthRx scores 9.0 to 7.8 — clearly ahead.
Support
Real clinician access, coaching and follow-up — video visits and a care team score higher than async-only. DirectMeds scores 7.2 to 7.0 — just ahead.
Medications
Medication options and legitimacy — FDA-approved branded (Wegovy, Zepbound) rates above compounded-only, and breadth and flexibility add points. DirectMeds scores 9.0 to 8.4 — ahead.
Transparency
How clearly and publicly pricing, terms and availability are stated — plus track record and any regulatory red flags. HealthRx scores 8.2 to 8.0 — just ahead.
Where they differ most
The clearest daylight is in value, where HealthRx leads 9.0 to 7.8 and medications, where DirectMeds leads 9.0 to 8.4. On price, HealthRx starts lower ($99 vs $179 per month).
Pricing: HealthRx vs DirectMeds
HealthRx has the lower advertised starting price — $99/mo vs $179/mo for DirectMeds. But read the fine print: HealthRx is all-in, includes medication and DirectMeds is all-in, includes medication, and the cheapest rates often need a prepaid multi-month plan — so compare the real all-in cost at your maintenance dose, not the headline. We unpack how these plans are structured in how much compounded semaglutide costs.
HealthRx: On 12-month plan; $133/mo (3-month) to $189/mo month-to-month; same price at every dose (as of 2026, matchglp1.com). DirectMeds: Sublingual/oral semaglutide; injectable semaglutide ~$297/mo, tirzepatide ~$399/mo (as of Sep 2026, clearmetabolic.com).
The specs, side by side
| HealthRx | DirectMeds | |
|---|---|---|
| Editor rating | 8.0/10 · Very good | 8.0/10 · Very good |
| Starting price | $99/mo | $179/mo |
| Pricing | All-in, includes medication | All-in, includes medication |
| Medications | Compounded semaglutide & tirzepatide | Compounded semaglutide & tirzepatide |
| Medication form | Weekly injection | Injection or sublingual |
| Visit type | Async health assessment | Async, reviewed within ~6h |
| Insurance | Cash-pay | Cash-pay (HSA/FSA) |
| Availability | Not clearly stated | ~45 states |
Which should you pick?
Choose DirectMeds if…
You want the broadest medication menu and the flexibility to switch or adjust dose.
View DirectMeds plans →Common questions
Is HealthRx better than DirectMeds?
They're line-ball on our rubric at 8.0/10, and HealthRx edges it on the lower starting price. It's our pick for most people; DirectMeds is the better choice if you want the broadest medication menu and the flexibility to switch or adjust dose.
Which is cheaper, HealthRx or DirectMeds?
HealthRx has the lower advertised starting price — $99/mo vs $179/mo for DirectMeds. But read the fine print: HealthRx is all-in, includes medication and DirectMeds is all-in, includes medication, and the cheapest rates often need a prepaid multi-month plan — so compare the real all-in cost at your maintenance dose, not the headline.
Do HealthRx and DirectMeds prescribe the same medications?
HealthRx offers compounded semaglutide & tirzepatide (weekly injection); DirectMeds offers compounded semaglutide & tirzepatide (injection or sublingual). On breadth of options, DirectMeds scores higher. Compounded GLP-1s aren't FDA-approved finished products, and availability shifts — confirm current options with each provider.
Which gives you more support, HealthRx or DirectMeds?
DirectMeds scores higher on support — real clinician access, coaching and follow-up. For visits, HealthRx is async health assessment and DirectMeds is async, reviewed within ~6h.
Are HealthRx and DirectMeds legit?
Both require a licensed clinician to review your intake before prescribing. Confirm each provider's credentials, state availability (HealthRx: not clearly stated; DirectMeds: ~45 states) and current pricing before you sign up — and note that compounded medications aren't FDA-approved.
Can I switch between HealthRx and DirectMeds?
Generally yes — neither locks you into a long contract, though the lowest prices often require a prepaid plan. Never stop or change a GLP-1 medication without talking to your clinician first.
Both programs are scored with the same independent methodology. We may earn a commission from either provider — it changes nothing about the scores or the verdict. Prices are advertised starting rates as of October 2026; confirm current pricing with each provider. Nothing here is medical advice.