Shed starts at $149/mo (all-in, includes medication); TrimRx at $179/mo (all-in, includes medication). Both prescribe GLP-1 medication — Shed offers compounded semaglutide & tirzepatide, TrimRx compounded + branded options. Here's how they compare on price, medications, support and transparency.
Bottom line: Shed wins
Shed wins on our rubric, 8.5/10 to 7.6/10. It leads most on support. Choose TrimRx instead if you'd rather use FDA-approved branded medication (Wegovy, Zepbound) than compounded-only.
Round by round
We scored both programs on the four factors in our methodology — value, support, medications and transparency. Shed takes 2, TrimRx takes 0, with 2 even. Here's how each shook out.
Value
What you get for the price — not just the lowest sticker. A premium program that includes FDA-approved medication, insurance help and real support can be good value. Evenly matched at about 7.8.
Support
Real clinician access, coaching and follow-up — video visits and a care team score higher than async-only. Shed scores 9.0 to 6.8 — clearly ahead.
Medications
Medication options and legitimacy — FDA-approved branded (Wegovy, Zepbound) rates above compounded-only, and breadth and flexibility add points. Evenly matched at about 9.0.
Transparency
How clearly and publicly pricing, terms and availability are stated — plus track record and any regulatory red flags. Shed scores 7.8 to 7.0 — clearly ahead.
Where they differ most
The clearest daylight is in support, where Shed leads 9.0 to 6.8 and transparency, where Shed leads 7.8 to 7.0. On price, Shed starts lower ($149 vs $179 per month).
Pricing: Shed vs TrimRx
Shed has the lower advertised starting price — $149/mo vs $179/mo for TrimRx. But read the fine print: Shed is all-in, includes medication and TrimRx is all-in, includes medication, and the cheapest rates often need a prepaid multi-month plan — so compare the real all-in cost at your maintenance dose, not the headline. We unpack how these plans are structured in how much compounded semaglutide costs.
Shed: Intro/platform rate; semaglutide injection commonly from $199/mo, dose-tiered; ~2-month minimum (as of Sep 2026, glpchart.com). TrimRx: Advertised 'from $179/mo'; semaglutide ~$199–$349/mo by plan length; branded far higher (as of Aug 2026, health.usnews.com).
The specs, side by side
| Shed | TrimRx | |
|---|---|---|
| Editor rating | 8.5/10 · Great | 7.6/10 · Good |
| Starting price | $149/mo | $179/mo |
| Pricing | All-in, includes medication | All-in, includes medication |
| Medications | Compounded semaglutide & tirzepatide | Compounded + branded options |
| Medication form | Injection, drops or lozenge | Weekly injection |
| Visit type | Async questionnaire | Async questionnaire (limited coaching) |
| Insurance | Cash-pay | Cash-pay (HSA/FSA) |
| Availability | All 50 states | Most US states |
Which should you pick?
Choose TrimRx if…
You'd rather use FDA-approved branded medication (Wegovy, Zepbound) than compounded-only.
View TrimRx plans →Common questions
Is Shed better than TrimRx?
In our scoring Shed comes out ahead — 8.5/10 to 7.6/10, leading on support. It's our pick for most people; TrimRx is the better choice if you'd rather use FDA-approved branded medication (Wegovy, Zepbound) than compounded-only.
Which is cheaper, Shed or TrimRx?
Shed has the lower advertised starting price — $149/mo vs $179/mo for TrimRx. But read the fine print: Shed is all-in, includes medication and TrimRx is all-in, includes medication, and the cheapest rates often need a prepaid multi-month plan — so compare the real all-in cost at your maintenance dose, not the headline.
Do Shed and TrimRx prescribe the same medications?
Shed offers compounded semaglutide & tirzepatide (injection, drops or lozenge); TrimRx offers compounded + branded options (weekly injection). On breadth of options, Shed scores higher. Compounded GLP-1s aren't FDA-approved finished products, and availability shifts — confirm current options with each provider.
Which gives you more support, Shed or TrimRx?
Shed scores higher on support — real clinician access, coaching and follow-up. For visits, Shed is async questionnaire and TrimRx is async questionnaire (limited coaching).
Are Shed and TrimRx legit?
Both require a licensed clinician to review your intake before prescribing. Confirm each provider's credentials, state availability (Shed: all 50 states; TrimRx: most us states) and current pricing before you sign up — and note that compounded medications aren't FDA-approved.
Can I switch between Shed and TrimRx?
Generally yes — neither locks you into a long contract, though the lowest prices often require a prepaid plan. Never stop or change a GLP-1 medication without talking to your clinician first.
Both programs are scored with the same independent methodology. We may earn a commission from either provider — it changes nothing about the scores or the verdict. Prices are advertised starting rates as of October 2026; confirm current pricing with each provider. Nothing here is medical advice.